Evaluation and Comparison of Histologic Changes in Extraction Sites Grafted with Simvastatin mixed with Nanobone

Document Type : Original Article

Authors

1 Department of Periodontology, Faculty of Dentistry, South Valley University, Qena

2 Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, South Valley University, Qena,

3 Department of Dental and Oral Biology, Faculty of Dentistry, Al-Azhar University (Boys Branch), Cairo, Egypt

Abstract

Objective: The objective of the present study was to compare the effect of mixing simvastatin with Nanobone graft on the
healing process of extraction sockets regarding to the histological parameter.
Materials and Methods: In a prospective randomized clinical study, ten patients (study group, Group II) treated by simvastatin
mixed with Nanobone after tooth extraction. The other ten patients (Control group, Group I) received Nanobone only. Three
months after tooth extraction and socket preservation, histological biopsies were taken at the time of implant placement. The
biopsies were evaluated in the terms of the histological parameter for the identification of vascularization and bone metabolism
factors.
Results: The use of simvastatin combination results in slightly higher values of mineralized area of newly formed bone
andnumerous well differentiated capillary vascularization.
Conclusion: Simvastatin and Nanobone combination showed improvement in socket preservation.

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History

  • Receive Date: 18 August 2020
  • Revise Date: 16 November 2020
  • Accept Date: 27 February 2021

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