Advanced-Platelet-Rich Fibrin Combination with Metformin for Surgical Correction of Periodontal Intrabony Defects: A Randomized Double Blinded Clinical Trial

Document Type : Original Article

Authors

1 Oral Medicine, Periodontology, Oral Diagnosis, and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University (Assiut branch), Assiut, Egypt

2 Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University(Assiut branch), Assiut, Egypt

3 Oral Biology Department, Assiut University, Assiut, Egypt

4 Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Assiut University, Assiut, Egypt

Abstract

Objective: This trial preformed to evaluate clinically and radiographically, the efficacy of growth factors producing/inducing
materials; Advanced-Platelet-Rich Fibrin (A-PRF) and Metformin (MF) respectively, in the surgical treatment of intrabony
periodontal defects.
Methods: Forty-eight systemically healthy chronic periodontitis patients with intrabony defect were divided equally into 4
groups. First Group, patients treated by open flap debridement (OFD). Second Group, patients treated by OFD + 1% MF gel.
Third Group, patients treated by A-PRF, which inserted into the intra bony defect (IBD). Fourth Group treated by (1% MF +
A-PRF). Parameters were gathered at baseline 6 and 9 months.
Results: The reduction in probing depth (PD) and clinical attachment level (CAL) was greater in the A-PRF + 1% MF patients
group than other groups. Combination of A-PRF + 1% MF showed statistically significant reduction of IBD greater than all
other groups.
Conclusions: Usage of combination of A-PRF + 1% MF seems to be superior in gaining bone than surgical treatment by OFD,
OFD + A-PRF or OFD + MF only.

Keywords

Egyptian Journal of Oral and Maxillofacial Surgery
Volume 12, Issue 4
October 2021
Pages 267-277

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History

  • Receive Date: 21 March 2022
  • Revise Date: 24 March 2022
  • Accept Date: 11 April 2022

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