Evaluating the effect of bleomycin injection in the head and neck hemangiomas and different types of low flow vascular malformation: cohort retrospective study

Document Type : Original Article

Authors

1 Cranio-Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

2 Cranio-Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Abstract

Introduction: Vascular anomalies are considered the most common form of congenital and neonatal dysmorphogenesis. They are classified into hemangiomas and vascular malformations (VMs) which are divided into high and low flow VMs which include venous, lymphatic, and combined lymphatico-
venous malformations. Different treatment modalities for vascular anomalies including sclerotherapy,
vessel embolization, surgical excision and a conjunction of these. Bleomycin developed as a cytotoxic antitumor agent Which has an antiproliferative effect. It has been become widely used for treatment of vascular anomalies because of its high sclerosing effect on vascular endothelium.
Objective: to evaluate clinical and radiological effect of bleomycin injection for the treatment
of head & neck hemangioma & different types of low flow vascular malformation.
Materials and Methods: a retrospective study was done on 25 patients with different types of vascular anomalies and were treated by intralesional bleomycin injection at the Department
craniomaxillofacial & plastic surgery at Alexandria university & Nile of hope hospital.
Results: The clinical, radiographical and patient satisfaction outcomes were markedly improved.
Conclusions: bleomycin injection into vascular lesion is a noninvasive modality
for vascular malformations treatment with excellent results and low cost.

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History

  • Receive Date: 04 June 2025
  • Accept Date: 13 June 2025

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