Infantile Central Myofibroma of the Mandible:

Document Type : Case Report

Authors

1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tanta University, Tanta, Egypt

2 Department of Oral Pathology, Faculty of Dentistry, Tanta University, Tanta, Egypt

Abstract

Oral myofibroma is an uncommon benign tumor that has great tendency to involve oral soft tissues with bony involvement
remains a rarity. Most myofibromas exhibit a benign slow clinical course however intra-osseous lesions could be mistaken
with many aggressive tumors which necessitate accurate diagnosis. The aim of this report is to shed light on a rare case
of infantile central myofibroma of the mandible. Case report: A 6-month-old girl presented with an expansible painless left
mandibular swelling. Radiographic examination revealed a well-defined, unilocular, radiolucent lesion with cortical erosions.
Histopathological examination showed a highly cellular, encapsulated mass comprised of spindle-shaped and smaller round
or polygonal cells in a vague biphasic pattern. Immunohistochemically, tumor cells showed strong cytoplasmic staining for
α-SMA, weak Ki-67 and negative desmin, CD34 and S-100 protein. Accordingly, conservative surgical excision with bone
curettage was performed. Postoperative follow-up revealed excellent healing with no evidence of recurrence.

Keywords